Brazilian Journal of Medical and Biological Research (2001) 34: 545-547 Propylene glycol and the hole-board ISSN 0100-879X Short Communication
Interference of propylene glycol with the hole-board test A. Lourenço da Silva1 and E. Elisabetsky1,2
de Pós-Graduação em Ciências Biológicas-Bioquímica and de Farmacologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil
Abstract Correspondence E. Elisabetsky Caixa Postal 5072 90041-970 Porto Alegre, RS Brasil E-mail: [email protected]
Research supported by CNPq (No. 522912/96.6), FAPERGS (No. 98/1610.3) and PROPESQ (No. 25/00).
Received August 21, 2000
Experimental drugs and/or plant extracts are often dissolved in solvents, including propylene glycol. Nevertheless, there is evidence for psychoactive properties of this alcohol. In this study we found that in the hole-board test 10% propylene glycol did not modify the headdipping behavior. However, 30% propylene glycol induced an increase in the number of head-dips (46.92 ± 2.37 compared to 33.83 ± 4.39, P